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DNA-damaging gut bacteria may fuel colon cancer in patients with inflammatory bowel disease



Scientists have discovered DNA-damaging molecules made by gut bacteria that may help explain why people with inflammatory bowel disease (IBD) have higher rates of colorectal cancer than those without the condition. 

In a new study, published Thursday (Oct. 27) in the journal Science (opens in new tab), researchers identified a previously unknown class of DNA-damaging molecules, or genotoxins, that they named the “indolimines.” These molecules are produced by Morganella morganii, a bacterium that proliferates in the guts of patients with IBD and those with colorectal cancer

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